Thermo Fisher Scientific PON3 Monoclonal Antibody (OTI1B12), TrueMAB
인간 PON3 단백질을 인식하는 단클론 항체로, Western blot 및 IHC(파라핀 절편)에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용되며, PON3 관련 산화 스트레스 및 동맥경화 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 30–319 of human PON3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL and prevents oxidation of LDL, reducing atherogenic oxidized-LDL formation.
Polymorphisms in the human PON1 gene correlate with coronary artery disease. Reduced PON1 activity is observed in individuals prone to atherosclerosis, such as those with diabetes, familial hypercholesterolemia, or renal disease.
PON2 and PON3 are related enzymes; PON3 shares similar activity to PON1 but differs in substrate specificity. Both PON1 and PON3 may lower the risk of coronary artery disease and atherosclerosis. Human PON3 shares conserved cysteine residues with PON1, suggesting functional importance in vivo. PON1-based catalytic scavengers are being explored for protection against organophosphate intoxication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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