Thermo Fisher Scientific mGLuR4 Recombinant Rabbit Monoclonal Antibody (6H26L4)
mGluR4 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 높은 특이성과 일관된 생산 로트 제공. 인간, 랫드 반응성 확인, 원숭이 등에도 예측 반응성 있음. 단백질 A 정제, PBS 완충액 내 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6H26L4 |
| Immunogen | Peptide corresponding to human mGluR4 [aa891–aa912] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2734819 |
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Rabbit, and Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
The Metabotropic Glutamate Receptor mGluR4 (GRM4) binds L-glutamate, the major excitatory neurotransmitter in the central nervous system. It activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is critical for normal brain function and is implicated in various neuropathologic conditions.
Metabotropic glutamate receptors are G protein-coupled receptors divided into three groups based on sequence homology, signaling mechanisms, and pharmacologic properties.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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