Thermo Fisher Scientific CRHR1 Recombinant Rabbit Monoclonal Antibody (4H5L2)
CRHR1 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF에 1:500 희석으로 사용 가능. 높은 특이성과 민감도, 로트 간 일관성, 동물 유래 성분 없음, 다양한 종에 반응 예측.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4H5L2 |
| Immunogen | Peptide corresponding to human CRHR1 [aa425–aa444] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2734802 |
Product Specific Information
This antibody is predicted to react with Monkey, Dog, Pig, Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1) is involved in mediating stress response and anxiety-related behaviors. Mutations in this receptor may reduce anxiety-related behaviors and contribute to Cushing disease pathogenesis. Multiple isoforms are produced by alternative splicing.
CRFR1 expression has been reported in pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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