Thermo Fisher Scientific NREP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.

Target Information

P311, also known as C5orf13 (chromosome 5 open reading frame 13), D4S114, PTZ17, or PRO1873, is a 68-amino-acid cytoplasmic protein involved in cellular differentiation, neural function, and axonal regeneration. It is found in the granular layer of the cerebellum and expressed at lower levels in hippocampus, olfactory bulb, kidney, liver, and heart. When expressed ectopically, P311 enhances glioma motility. In mice, P311 is enriched within the superficial cortical layers and striatum at E20 and in germinal zones at E17. Known to interact with Filamin 1, P311 regulates retinoic acid lipid-droplet biogenesis, induces myofibroblast ameboid migration, and promotes fibroblast-to-myofibroblast differentiation. Ser-59 phosphorylation decreases P311 stability. The gene encoding P311 maps to human chromosome 5q22.1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.