Thermo Fisher Scientific BTRC Polyclonal Antibody
Thermo Fisher Scientific의 BTRC Polyclonal Antibody는 인간, 생쥐, 랫트에 반응하는 rabbit IgG 형 항체로, WB, IHC, ICC/IF에 사용 가능합니다. 1 mg/mL 농도로 액상 형태이며, PBS 버퍼에 보관됩니다. 세포 및 조직 내 BTRC 단백질 검출에 적합합니다.
- 카탈로그번호
- PA5144646
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human Beta TRCP aa 1–200/605 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3093522 |
Product Specific Information
- Positive control: HepG2, HeLa, 293T cell lysate; mouse testis, rat brain, mouse brain tissue lysate; A549; human colon tissue; mouse large intestine tissue
- Predicted band size: 69 kDa
- Subcellular Location: Cytoplasm, Nucleus
Target Information
This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. F-box proteins are part of the SCF ubiquitin ligase complex (SKP1-cullin-F-box), functioning in phosphorylation-dependent ubiquitination.
F-box proteins are divided into three classes:
- Fbws with WD-40 domains
- Fbls with leucine-rich repeats
- Fbxs with other protein-protein interaction modules or no recognizable motifs
The encoded protein belongs to the Fbws class and contains multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins. It interacts with HIV-1 Vpu, connecting CD4 to the proteolytic machinery, and associates with phosphorylated IkappaBalpha and beta-catenin destruction motifs.
This protein likely functions in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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