Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody
Human Apolipoprotein J를 검출하는 Goat Polyclonal Antibody로, WB, IHC, ELISA, IP에 적합. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:10,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:50–1:200 | - |
| ELISA | 1:5,000–1:10,000 | View 1 publication |
| Immunoprecipitation (IP) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified, full-length, native Apolipoprotein type J |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.125M sodium borate, pH 8.0, with 5mM EDTA, 0.075M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2083334 |
Product Specific Information
PA1-26903 detects Apolipoprotein J from human samples.
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of plasma proteins. It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro). It does not require ATP and maintains partially unfolded proteins for refolding by other chaperones such as HSPA8/HSC70. It does not refold proteins by itself.
Binding to cell surface receptors triggers internalization and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and complement-mediated cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes to promote ubiquitination and degradation of target proteins, including COMMD1 and IKBKB, and modulate NF-kappa-B activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms suppress BAX-dependent cytochrome c release and inhibit apoptosis. Plays a role in regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA1-26903_Apolipoprotein_J_P10909-1_Goat.svg
- PA1-26903_Apolipoprotein_J_P10909-1_Goat_PDP.jpeg
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