Thermo Fisher Scientific Apolipoprotein B Polyclonal Antibody
Human Apolipoprotein B를 인식하는 Goat Polyclonal Antibody로, WB, IHC, ELISA, IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. LDL 관련 연구 및 동맥경화 기전 분석에 적합.
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- PA126901
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Thermo Fisher Scientific Apolipoprotein B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:500 |
| ELISA | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified, full-length, native Apolipoprotein type B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.125M sodium borate, pH 8.0, with 0.075M NaCl, 5mM EDTA |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_779273 |
Product Specific Information
PA1-26901 detects Apolipoprotein B from human samples.
Target Information
Apolipoprotein B (apo B) is a major protein of low-density lipoproteins (LDL) in human plasma, with a molecular mass of approximately 260–500 kDa. It binds to specific receptors on cell membranes and plays a critical role in the removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.
LDL serves as the carrier protein for cholesterol in the blood, mediating uptake and clearance via LDL receptors. In atherosclerotic lesions, oxidized LDL is recognized and ingested by macrophages through scavenger receptors such as A and CD36. Elevated Apolipoprotein B levels are associated with premature atherosclerosis.
Apolipoprotein B occurs mainly as two isoforms, apoB-48 and apoB-100, encoded by a single gene. ApoB-48 is produced by RNA editing of apoB-100 mRNA, introducing a stop codon at residue 2180. Mutations in the Apolipoprotein B gene can lead to hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective forms.
Normal plasma Apolipoprotein B levels are approximately 800 mg/L.
Usage Note
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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