Thermo Fisher Scientific Androgen Receptor Polyclonal Antibody
Thermo Fisher Scientific의 Androgen Receptor Polyclonal Antibody는 인간 AR의 N-말단 펩타이드로부터 유래된 면역원으로 제작된 토끼 IgG 항체입니다. WB, IHC(P), IHC(F)에 사용 가능하며, 다양한 종에서 교차 반응성을 예측합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:400 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from near N-terminus of human AR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2274362 |
Product Specific Information
This antibody is predicted to react with canine, mouse, porcine, and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10 mM citrate buffer (pH 6.0) for 10 minutes followed by cooling at room temperature for 20 minutes.
Following antigen retrieval, incubate samples with primary antibody for 10 minutes at room temperature.
A suggested positive control is prostate carcinoma.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT).
Upon ligand binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling plays a key role in the development and function of male reproductive organs such as the prostate and epididymis, and also affects nonreproductive tissues like muscle, hair follicles, and brain.
Abnormalities in AR signaling are linked to diseases including prostate cancer, Kennedy’s disease, and male infertility.
Mutations in the AR gene are associated with complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA1-37079_Androgen_Receptor_P10275-1_Rabbit.svg, PA1-37079_Androgen_Receptor_P10275-1_Rabbit_PDP.jpeg)
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