Thermo Fisher Scientific CD18 Monoclonal Antibody (MEM-48)

Thermo Fisher Scientific CD18 Monoclonal Antibody (MEM-48)

Applications and Tested Dilution

Product Specifications

Available Conjugated Formats

• APC
• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope involving residues 534–546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit). CD18 is a 90–95 kDa type I transmembrane protein expressed on all leukocytes.
It does not cross-react with canine.
Endotoxin level is less than 0.01 EU/µg of protein (LAL test).
Western Blot: non-reducing conditions; Functional Application: Induction.

Target Information

CD18 (integrin beta 2 subunit) is a 90 kDa type I transmembrane protein expressed on all leukocytes. It forms heterodimers with CD11 molecules (CD11a–d) to constitute leukocyte (β2) integrins, including:

• αLβ2 (CD11a/CD18, LFA-1)
• αMβ2 (CD11b/CD18, Mac-1, CR3)
• αXβ2 (CD11c/CD18)
• αDβ2 (CD11d/CD18)

These integrins are essential for leukocyte migration and intercellular adhesion.
Defects in the CD18 gene cause leukocyte adhesion deficiency type I (LAD1).
CD18 is also targeted by Mannheimia haemolytica leukotoxin, mediating cytolysis.
Two transcript variants encoding CD18 protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)