Thermo Fisher Scientific CD20 Monoclonal Antibody (MEM-97)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1–5 µg/mL

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody reacts with an extracellular epitope on CD20 (Bp35), a 33–37 kDa non-glycosylated membrane receptor with four transmembrane domains. It is expressed on B lymphocytes (lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.

Target Information

CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells. It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. CD20 serves as a target for antibody-mediated therapeutic depletion of B cells, as it remains on the cell surface without internalization or shedding after antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.