Thermo Fisher Scientific p21 Monoclonal Antibody (WA-1)
p21 단백질을 인식하는 WA-1 클론의 마우스 단클론 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human 및 비인간 영장류 반응성. Protein A 정제, PBS 용액 형태, 4°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WA-1 |
| Immunogen | Full length native protein (purified) (Human) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1959169 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Protein p21 is a tumor suppressor protein that inhibits cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. p21 plays a crucial role in the cellular response to genotoxic stress and acts as a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits CDK1 and CDK2, blocking cell cycle progression from G1 to S or G2 to M phase after DNA damage, allowing DNA repair.
In the cytoplasm, p21 exhibits anti-apoptotic effects by binding to and inhibiting caspase 3, ASK1, and JNK.
p21 has a dual role in carcinogenesis, functioning both as a tumor suppressor and as an oncogene depending on the context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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