Thermo Fisher Scientific ACVR2A Monoclonal Antibody (A7C8)
ACVR2A 단백질을 인식하는 Mouse monoclonal antibody (Clone A7C8). Western blot에 1:1,000 희석 비율로 검증됨. Human 시료에 반응하며, 단백질 A로 정제된 액상 형태. 단기 보관은 4°C, 장기 보관은 -20°C 권장.
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A7C8 |
| Immunogen | Synthetic peptide within Human ACVR2A aa 464–513/513 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091320 |
Product Specific Information
- Positive control: K562 cell lysate, HepG2 cell lysate
- Predicted band size: 58 kDa
- Subcellular Location: Membrane
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A is involved in the activin and myostatin signaling pathway.
Aliases: ACVR2, ACTRII.
These receptors are transmembrane proteins composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
After ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors.
Type II receptors are considered constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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