Thermo Fisher Scientific ISG15 Recombinant Rabbit Monoclonal Antibody (239)

Applications

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody specifically recognizes Human ISG15.

Target Information

Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection, either via conjugation to target proteins (ISGylation) or as a free protein.
It is secreted from monocytes in response to type I interferons, promoting NK-cell proliferation and enhancing non-MHC-restricted cytotoxicity.
Expression is induced by IFN-α, IFN-β, and IFN-ω, but not IFN-γ, and can also be stimulated by influenza B virus or interferon regulatory factors.

ISG15 is secreted by monocytes, T-lymphocytes, B-lymphocytes, fibroblasts, and epithelial cells. It acts as part of the cytokine cascade, amplifying immunomodulatory effects of interferons. Intracellularly, ISG15 functions as a ubiquitin homolog.
Mutations in the ISG15 gene can cause Immunodeficiency 38 with basal ganglia calcification (IMD38).

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.