Thermo Fisher Scientific RAB23 Monoclonal Antibody (OTI2A8)
RAB23 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, Affinity chromatography로 정제된 액상형 항체. 세포 내 단백질 수송 및 Rab 단백질 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–234 of RAB23 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725169 |
Target Information
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec, and Rho/Rab subfamilies. Rab proteins play an important role in endocytosis and biosynthetic protein transport. Transport of newly synthesized proteins from the endoplasmic reticulum to Golgi stacks and secretory vesicles requires Rab protein function. Rab proteins are also integral to endocytic pathways.
Rab23 (also known as HSPC137) is a 237 amino acid member of the Rab family that localizes to the cytoplasmic side of the cell membrane. It is involved in intracellular protein transport and GTPase-mediated signal transduction. Mutations in the Rab23 gene are associated with Carpenter syndrome (ACPS2), characterized by obesity, cardiac defects, polysyndactyly, and craniosynostosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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