Thermo Fisher Scientific Phospho-Histone H2A.X (Ser139) Recombinant Rabbit Monoclonal Antibody (HisH2AXS139-1B3), APC
Recombinant rabbit monoclonal antibody recognizing phospho-Histone H2A.X (Ser139). APC-conjugated for flow cytometry detection of DNA double-strand breaks. Reacts with human and mouse samples. Supplied as liquid in PBS with BSA and sodium azide, stored...
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Applications
- Flow Cytometry (Flow): 5 µL per 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HisH2AXS139-1B3 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho-histone H2A.X |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896960 |
Additional Formats
Target Information
Histone H2A.X (H2AX) is a member of the histone H2A family, one of the four core histones forming the nucleosome core particle. DNA double-strand breaks (DSBs) trigger phosphorylation of serine 139 at the C-terminus of H2AX, resulting in γ-H2AX formation. This phosphorylation can be detected by Western blotting or immunofluorescence, providing a marker for DSB frequency.
Phosphorylation is mediated by phosphatidylinositol 3-kinases, including ATM, DNA-PK, and ATR. H2A.X contains 143 amino acids and is synthesized in both G1 and S phases. Two mRNA forms exist: a 1600-base polyA+ form and a 575-base replication-type form lacking polyA. The gene maps to human chromosome 11q23.2–q23.3. H2A.X plays a key role in chromatin structure and DNA damage response by mediating MDC1 recruitment to DNA damage sites.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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