Thermo Fisher Scientific ZEB2 Monoclonal Antibody (OTI15G8), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ZEB2, also known as Smad-interacting protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs. Similar to ZEB1, it inhibits E-cadherin transcription and induces epithelial-mesenchymal transition (EMT), a process involved in cell migration during embryonic development and wound healing.
ZEB2 can protect cells from DNA damage-induced apoptosis, potentially contributing to tumor progression. It has been observed in the cytoplasm of various cancer tissues, suggesting regulated localization in normal and tumor contexts.
Mutations in the ZEB2 gene are associated with Hirschsprung disease and Mowat-Wilson syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.