Thermo Fisher Scientific CD50/ICAM3 Recombinant Mouse Monoclonal Antibody (rICAM3, 1019)
CD50/ICAM3 단백질을 인식하는 Thermo Fisher의 재조합 마우스 단일클론 항체입니다. 인간 ICAM3에 특이적이며 IHC(P) 적용에 적합합니다. 고순도 Protein A/G 정제, 액상 형태로 제공되며 4°C에서 안정적으로 보관됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rICAM3, 1019 |
| Immunogen | Recombinant full-length human ICAM3 protein (CD50, UniProt ID: P32942-1, Range: 1–547) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes and serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin.
ICAM-3 functions as an adhesive molecule mediating contact between T cells and antigen-presenting cells, regulates LFA-1 affinity for ICAM-1, and induces T cell activation and proliferation.
It plays an essential role in initiating immune responses and interacts with CD209 (DC-SIGN), facilitating communication between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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