Thermo Fisher Scientific Cyclin L1 Polyclonal Antibody
Human Cyclin L1a에 특이적인 Rabbit Polyclonal Antibody로 Western blot, IHC, ELISA, IP 등에 사용 가능. Protein A로 정제된 Lyophilized 형태이며 4°C 단기 보관, -20°C 장기 보관 권장. 다양한 종에서 높은 교차 반응성을 보임.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:5,000 |
| Immunohistochemistry (IHC) | 10–20 µg/mL |
| ELISA | 1:5,000–1:25,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic polypeptide corresponding to an internal region near amino acids 300–375 of Human Cyclin L1a protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 5 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for human Cyclin L1a and shows negligible reactivity to Cyclin L1b or Cyclin L2 isoforms.
BLAST analysis suggests reactivity with human and chimpanzee based on 100% homology for the immunogen sequence.
Cross-reactivity with Cyclin L1a protein from dog, rat, mouse, and chicken is expected (87–96% homology).
Cross-reactivity with other homologues has not been determined.
Target Information
FUS/TLS (Fused in Sarcoma) is involved in multiple cellular processes and associated with several diseases.
It binds DNA (single or double strand) and acts as a recognition site for transcription factors.
FUS is implicated in liposarcoma, lipoma, leukemia, and amyotrophic lateral sclerosis (ALS).
Disruption of its RNA-binding functions leads to mislocalization and neuronal pathologies.
Proper FUS regulation is essential for maintaining healthy cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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