Thermo Fisher Scientific CD218a (IL-18Ra) Monoclonal Antibody (H44), APC, eBioscience
인간 IL-18 수용체 알파(IL-18Ra)를 인식하는 마우스 단클론 항체로, APC 형광 표지되어 있습니다. 유세포 분석(Flow Cytometry)에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. 친화 크로마토그래피로 정제되었으며, 4°C 암소 보관이 권장됩니다.
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Thermo Fisher Scientific CD218a (IL-18Ra) Monoclonal Antibody (H44), APC, eBioscience™
Applications
- Flow Cytometry (Flow): 5 µL (0.25 µg)/test
- Tested and validated for use in normal human peripheral blood cells
- Recommended to stain whole blood before RBC lysis
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H44 |
| Conjugate | APC |
| Excitation/Emission Max | 651/660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573258 |
Available Formats
Product Specific Information
The H44 antibody reacts with the interleukin-18 receptor alpha chain (IL-18Ra), also known as IL-1Rrp, a member of the IL-1 receptor family.
IL-18R alpha is expressed on Th1 cells, NK cell subsets, neutrophils, and IL-12-stimulated tonsillar B cells.
- IL-18R alpha alone binds IL-18 with low affinity.
- When complexed with IL-18R beta chain, it binds IL-18 with high affinity.
- The IL-18/IL-18R complex plays a critical role in innate and autoimmune immune responses.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested for flow cytometry using human peripheral blood cells
Recommended Use: 5 µL (0.25 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL18R1 is a cytokine receptor belonging to the interleukin 1 receptor family. It specifically binds interleukin-18 (IL18) and is essential for IL18-mediated signaling.
Expression of this receptor is induced by IFN-α and IL-12 in NK and T cells.
The IL18R1 gene, along with IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), forms a gene cluster on chromosome 2q.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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