Thermo Fisher Scientific IL-22 Monoclonal Antibody (IL22JOP), APC, eBioscience
IL-22를 인식하고 억제하는 Rat IgG2a 단클론 항체로, APC로 표지되어 Flow Cytometry에 적합합니다. 인간, 마우스, 원숭이에 반응하며 Th17 세포 연구 및 염증 관련 질환 분석에 활용됩니다. 0.2 mg/mL 액상 형태로 제공되며 4°C 암소 보관이 권장됩니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-22 Monoclonal Antibody (IL22JOP), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.25 µg/test | View 44 publications |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rhesus monkey |
| Published Species | Human, Mouse, Non-human primate, Rhesus monkey |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL22JOP |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10597584 |
Additional Formats
Product Specific Information
The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20 kDa member of the IL-10 cytokine family, secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF-beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells, suggesting IL-22 secretion from more fully differentiated Th17 cells in vivo.
IL-22 has been shown to protect hosts from bacterial infections of the lungs and gut. Elevated IL-22 production has been observed in PBMCs from asthma patients, and increased IL-17⁺IL-22⁺ CD4 T cells have been found in ankylosing spondylitis and rheumatoid arthritis patients.
IL22JOP is reported to recognize rhesus IL-22.
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Tested on Th17-polarized CD4⁺ normal human peripheral blood cells. Recommended ≤0.25 µg/test (100 µL final volume). Cell numbers may range from 10⁵ to 10⁸ cells/test.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and a member of the IFN–IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons). It is produced mainly by activated T cells and NK cells. In humans, the IL-22 gene is located on chromosome 12q and is structurally related to IL-10.
IL-22 acts via a heterodimeric receptor complex composed of IL-22R1 and IL-10R2, activating the JAK-STAT signaling pathway. A soluble receptor, IL-22BP, antagonizes IL-22 binding and signaling. IL-22 primarily targets nonimmune cells such as epithelial cells, hepatocytes, and keratinocytes, influencing innate immunity, wound healing, and inflammation.
IL-22 is co-expressed with IL-17A and IL-17F by Th17 cells but is differentially regulated. It induces acute phase reactants, antimicrobial proteins, and keratinocyte mobility. IL-22 is upregulated during chronic inflammation and plays a critical role in defense against extracellular pathogens and tissue repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.