Thermo Fisher Scientific H4R3me1 Recombinant Rabbit Monoclonal Antibody (RM195)
Histone H4R3me1에 특이적인 재조합 토끼 단클론 항체로 높은 특이성과 재현성을 제공. Western blot, ICC/IF, ELISA, Luminex 등 다양한 응용 가능. 동물 유래 성분 없는 포뮬레이션으로 로트 간 일관성 보장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| ELISA | 0.2–1 µg/mL |
| Luminex (LUM) | 0.2–1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM195 |
| Immunogen | Monomethyl-peptide corresponding to the Monomethyl-Histone H4 (Arg3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2–7.4, with 50% glycerol, 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2661892 |
Product Specific Information
This antibody reacts to Histone H4 monomethylated at Arginine 3 (R3me1).
No cross-reactivity with unmodified Arginine 3, asymmetric or symmetric dimethylated Arginine 3, or citrullinated Arginine 3 in Histone H4.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to larger rabbit immune repertoire
Target Information
Histones are basic nuclear proteins responsible for the nucleosome structure of the chromosomal fiber in eukaryotes.
Two molecules of each core histone (H2A, H2B, H3, and H4) form an octamer around which ~146 bp of DNA is wrapped in repeating units called nucleosomes.
The linker histone H1 interacts with linker DNA between nucleosomes and functions in chromatin compaction.
The Histone H4 gene is intronless, lacks polyA tails, and contains a palindromic termination element. It is located in the large histone gene cluster on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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