Thermo Fisher Scientific TRPM6 Polyclonal Antibody
TRPM6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인체 TRPM6 합성 펩타이드로 면역화됨. 마그네슘 항상성 연구에 유용하며, 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human TRPM6 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2287837 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
Target Information
TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain.
TRPM6 is crucial for magnesium homeostasis and plays an essential role in epithelial magnesium transport and active magnesium absorption in the gut and kidney.
Isoforms of the type M6-kinase lack the ion channel region. Mutations in TRPM6 are associated with hypomagnesemia with secondary hypocalcemia.
Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
TRPC7 is thought to form a receptor-activated non-selective calcium permeant cation channel, operated by phosphatidylinositol second messenger systems activated by receptor tyrosine kinases or G-protein coupled receptors.
TRPC7 is also activated by diacylglycerol (DAG) and may be activated by intracellular calcium store depletion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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