Thermo Fisher Scientific ADAMTS4 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 12 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Elephant, Panda, Horse, Pig, Opossum (100%); Guinea pig (94%).

For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

This gene encodes a member of the ADAMTS protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
The enzyme encoded by this gene lacks a C-terminal TS motif and is responsible for the degradation of aggrecan (a major proteoglycan of cartilage) and brevican (a brain-specific extracellular matrix protein).
The cleavage of these substrates suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially in glioma progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.