Thermo Fisher Scientific NSE Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

Target Information

Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse in gluconeogenesis. NSE is highly stable in biological fluids and can diffuse into extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are injured.

NSE is one of three mammalian enolases (ENO1, ENO2, ENO3; also known as enolase α, β, γ).

• The α-subunit is expressed in most tissues
• The β-subunit only in muscle
• The γ-subunit primarily in neurons and neuroendocrine cells

Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms. Neurons, which require high energy, contain abundant glycolytic enzymes such as GAPDH and NSE. Antibodies to NSE are useful for identifying neuronal cell bodies, developing neuronal lineage, and neuroendocrine cells.

Release of NSE from damaged neurons into CSF and blood serves as a biomarker of neuronal injury. Clinically, NSE is used as a sensitive marker for neuronal damage in neurological disorders such as stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Elevated NSE levels are also observed in plasma and neoplasias including pediatric neuroblastoma and small cell lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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