Thermo Fisher Scientific MRP5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total ABCC5 protein.

Target Information

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
This protein belongs to the MRP subfamily, which is involved in multi-drug resistance and functions in cellular export of cyclic nucleotides.
This export contributes to phosphodiesterase degradation and may serve as an elimination pathway for cyclic nucleotides.
Studies indicate that this protein provides resistance to thiopurine anticancer drugs (6-mercatopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine.
It may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.
Alternative splicing has been detected, though the complete sequence and translation initiation site remain unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.