Thermo Fisher Scientific KISS1 Polyclonal Antibody
KISS1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot 및 IHC(Paraffin)에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C에서 보관합니다.
- 카탈로그번호
- PA550513
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:5–1:20 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminal of human KiSS-1 metastasis-suppressor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635966 |
Product Specific Information
This antibody detects endogenous levels of total KISS1 protein.
Target Information
The KISS1 gene functions as a metastasis suppressor, inhibiting metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. It may also regulate events downstream of cell-matrix adhesion, possibly involving cytoskeletal reorganization.
Kisspeptin, a product of this gene, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates pubertal activation of GnRH neurons.
A polymorphism in the terminal exon results in two protein isoforms; absence of an adenosine at the polymorphic site leads to utilization of a downstream stop codon and an extended protein by seven amino acid residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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