Thermo Fisher Scientific Adenylosuccinate Lyase/ADSL Polyclonal Antibody
Rabbit polyclonal antibody against human Adenylosuccinate Lyase (ADSL). Validated for WB and IP applications. Affinity purified with 1 mg/mL concentration. Suitable for research use in purine biosynthesis studies. Recommended storage at 4°C.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200–250 of human Adenylosuccinate Lyase (ADSL) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Adenylosuccinate Lyase (ADSL), also known as AMPS, ASL, or ASASE, is a 484-amino-acid enzyme involved in purine biosynthesis and AMP formation from inosine monophosphate. ADSL catalyzes two key reactions in AMP biosynthesis:
- Removal of fumarate from succinylaminoimidazole carboxamide ribotide (SAICA ribotide) to yield aminoimidazole carboxamide ribotide (AICA ribotide).
- Removal of fumarate from adenylosuccinate to produce AMP.
Defects in the ADSL gene cause adenylosuccinase deficiency, an autosomal recessive disorder characterized by epilepsy, growth retardation, and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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