Thermo Fisher Scientific CD105 Monoclonal Antibody (MEM-226), Alexa Fluor 488
CD105(Endoglin)을 인식하는 Alexa Fluor 488 결합 단클론 항체로, 인간 및 랫드 시료에 반응합니다. Flow cytometry 및 Western blot에 적합하며, 혈관내피세포 및 특정 골수세포 표지에 유용합니다. 4°C 암조건에서 보관하며 동결 금지.
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Applications
- Western Blot (WB): Assay-dependent
- Flow Cytometry (Flow): 4 µL / 100 µL whole blood or 10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-226 |
| Immunogen | Recombinant Vaccinia virus containing the human CD105 cDNA |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539494 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow. It is also present on syncytiotrophoblast on placenta throughout pregnancy.
Target Information
CD105 (Endoglin) is a Type I transmembrane protein highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Upregulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it serves as a proliferation-associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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