Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), Alexa Fluor 488

Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), Alexa Fluor 488

Applications and Tested Dilution

• Immunocytochemistry (ICC/IF): Assay-dependent
• Flow Cytometry (Flow): 4 µL per 100 µL whole blood or 10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD11b (Mac-1 alpha), a 165–170 kDa type 1 transmembrane protein mainly expressed on monocytes, granulocytes, and NK cells.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex, known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3), serves as a receptor for ICAM-1, ICAM-2, ICAM-4, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X.
CD11b is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, subsets of NK and dendritic cells, and microglia. It is a key marker for microglia and varies in expression with macrophage maturation and tissue type.
CD11b dysfunction is associated with systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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