Thermo Fisher Scientific HRH4 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 12–24 µg/mL

Product Specifications

Product Specific Information

By immunohistochemistry, OPA1-15360 detects the Histamine H4 receptor in formalin-fixed, paraffin-embedded human tissues.

Target Information

The Histamine H4 receptor has been reported in human peripheral blood leukocytes, bone marrow, colon, liver, lung, small intestine, spleen, testis, thymus, tonsil, and trachea. Unlike the mouse H4 receptor, the human gene was not detected in the brain.

G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, with over a thousand predicted members. All GPCRs share a structural motif of seven membrane-spanning helices and exist in both active and inactive forms. Ligand binding induces conformational changes that trigger G-protein-mediated signaling and downstream effects. Negative regulation mechanisms of GPCRs play crucial roles in cellular physiology and are key targets in pharmacological research. Notably, drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) are GPCR-targeted pharmaceuticals with major market impact.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.