Merck Anti-SOX17

Anti-SOX17

from rabbit, purified by affinity chromatography

Transcription factor SOX-17

Transcription factor SOX-17 (UniProt: Q61473; also known as SOX-17) is encoded by the Sox-17 gene (Gene ID: 20671) in murine species. Sox17 protein belongs to the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and cell fate determination.

It binds to the sequences 5′-AACAAT-3′ or 5′-AACAAAG-3′ and modulates transcriptional regulation via WNT3A. Sox17 acts upstream of the Notch system and downstream of the canonical Wnt system, linking both signaling pathways.

Sox17 is involved in the formation and differentiation of endodermal tissues such as pancreatic and liver cells. It is a key regulator of human primordial germ cell (hPGC) fate and serves as one of the earliest markers. Additionally, SOX17 regulates oligodendrocyte progenitor cells, maintains fetal hematopoietic stem cells, and mediates cardiac muscle cell formation.

SOX17 is selectively expressed in arterial endothelial cells during early embryonic development and maintains this distribution postnatally and in adulthood. Inactivation of SOX17 in endothelial cells of mouse embryos results in lack of arterial differentiation and vascular remodeling, leading to embryonic death in utero.

References:

• Corada, M., et al. (2013). Nature Communications 4, 2609.
• Niakan, K.K., et al. (2010). Genes & Development 24(3): 312–326.

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