Merck Anti-Rubicon antibody, Mouse monoclonal

Anti-Rubicon antibody, Mouse monoclonal

clone RB-145, purified from hybridoma cell culture

Beclin-1 associated RUN domain containing protein, KIAA0226, Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, RUBCN, SCAR15

Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) also known as Beclin-1 associated RUN domain containing protein (Baron) or KIAA0226, is a negative regulator of endosomes maturation and endocytic trafficking.1-2 Rubicon knockdown studies showed enhanced autophagosome maturation and endocytosis.1 It also have a critical role in the LC3-associated phagocytosis (LAP) a noncanonical autophagy process which can be induced through the activation of extracellular receptor by different stimulators including pathogens, immune complexes and dying cells.4-5