Merck Anti-TFE3 antibody, Mouse monoclonal

Anti-TFE3 antibody, Mouse monoclonal

clone TFE3-37, purified from hybridoma cell culture

Class E basic helix-loop-helix protein 33, Transcription factor E3, bHLHe33

생물학적 소스

mouse

항체 형태

purified from hybridoma cell culture

클론

TFE3-37, monoclonal

form

buffered aqueous solution

분자량

60 kDa

species reactivity

mouse, canine, human, rat, bovine

포장

antibody small pack of 25 μL

농도

~1 mg/mL

technique(s)

immunoblotting: 1.5-3 μg/mL using human A549 cells extract

동형

IgG1

UniProt 수납 번호

P19532

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... TFE3(7030)

Transcription factor E3 (TFE3), also known as Class E basic helix-loop-helix protein 33 (bHLHe33), is a transcriptional activator that mediates the enhancer-promoter interactions. TFE3 belongs to the MiT family of helix-loop-helix leucine zipper transcription factors, it is ubiquitously expressed and can directly associate with DNA as either homodimer or heterodimer which are formed with two other MiT family members, TFEB or TFEC.
TFE3 serve an important role in cell growth, cell proliferation, cellular adaptation to starvation and cellular response to ER stress. Under nutrient-rich conditions, TFE3 is located in the cytoplasm, and under starvation conditions or treatment with ER stressors, TFE3 rapidly translocates to the nuclear. In the nuclear localization, TFE3 mediates cellular adaptation to stress by simultaneously promoting lysosomal biogenesis, autophagy induction, as well as expression of critical mitochondrial and metabolic regulators. It been shown that TFE3 also participate in the transcriptional regulation of the innate immune response.
Pathogen infections promote TFE3 nuclear translocation, thus inducing In vivo expression of several cytokines and chemokines.