Merck Anti-ABCA4 Antibody, clone 5B4

Anti-ABCA4 Antibody, clone 5B4

clone 5B4, from mouse

Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein

Quality Level

100

생물학적 소스

mouse

항체 형태

purified antibody

antibody product type

primary antibodies

클론

5B4, monoclonal

species reactivity

human, bovine

species reactivity (predicted by homology)

mouse (based on 100% sequence homology)

포장

antibody small pack of 25 μg

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

동형

IgG2bκ

NCBI 수납 번호

NP_000341.2

UniProt 수납 번호

P78363

배송 상태

ambient

Retinal-specific ATP-binding cassette transporter (UniProt: P78363; also known as ATP-binding cassette sub-family A member 4, ABCA4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein) is encoded by the ABCA4 (also known as ABCR) gene (Gene ID: 24) in human. ABCA4 is a multi-pass membrane protein that is exclusively expressed in retina and is found in the rims of rod photoreceptor cells. It contains two ABC transporter domains (aa 929-1160 and 1938-2170). In the visual cycle, it act as a retinal extruder or retinal-phosphatidylethanolamine flippase to facilitate the removal of all-trans-retinal from disc membranes following the photobleaching of rhodopsin. Mutations in ABCA4 gene are reported to cause Stargardt disease, which is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. It has also been linked to age-related macular degeneration and retinitis pigmentosa.