Merck Anti-Bmi-1 Antibody, clone F6

Anti-Bmi-1 Antibody, clone F6

clone F6, Upstate®, from mouse

Polycomb group RING finger protein 4, RING finger protein 51

Quality Level

100

생물학적 소스

mouse

항체 형태

affinity isolated antibody

antibody product type

primary antibodies

클론

F6, monoclonal

species reactivity

human, mouse, rat, rabbit

포장

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

동형

IgG1

NCBI 수납 번호

NM_005180

UniProt 수납 번호

P25916
P35226

배송 상태

ambient

Gene Information

human ... BMI1(648)

The Bmi1 protein is a member of the polycomb group (PcG) proteins. PcG proteins form multiprotein complexes that function as transcriptional repressors.
Several lines of evidence implicate Bmi1 in tumorigenesis. Firstly, Bmi1 cooperates with c-Myc in the generation of lymphomas in double transgenic mice. Secondly, Bmi1 blocks senescence and immortalizes mouse embryo fibroblasts, although not human fibroblasts, and in combination with an activated H-ras gene leads to neoplastic transformation. Thirdly, the BMI1 gene is amplified in certain mantle cell lymphomas and is overexpressed in a subset of non-small cell lung cancer, colorectal carcinomas, multiple myelomas and medulloblastomas, but not glioblastomas. Fourthly, the transformation of human hematopoietic progenitor cells by the oncogenic fusion protein E2a-Pbx1 requires Bmi1. Indeed, based on a list of genes differentially expressed in a mouse model of metastatic prostate cancer on a wild-type and bmi1-deficient genetic background a gene signature was recently identified that may predict response to therapy and survival in multiple types of cancer.