Merck Anti-B23 antibody, Mouse monoclonal

Anti-B23 antibody, Mouse monoclonal

Clone FC82291, Purified from Hybridoma Cell Culture

Anti-NPM, Anti-Nucleophosmin

B23 (also known as NPM, nucleophosmin, numatrin, or NO38) is a phosphoprotein widely expressed in all cell types and localized in granular regions of the nucleolus associated with pre-ribosomal particles.

This protein is involved in several nuclear functions such as:

• Assembly and/or intranuclear transport of preribosomal particles
• Cytoplasmic/nuclear trafficking
• Regulation of DNA polymerase A activity
• Centrosome duplication

Phosphorylation of B23 is mediated by a cyclin complex, CDK2/cyclin E. Phosphorylation causes the dissociation of B23 from the centrosome and enables duplication of the centrosome during cell mitosis.

B23 is also implicated in pro-myelocytic leukemia, where the B23 gene fuses with the retinoic acid receptor α (RARα) gene, producing a fusion protein (60–70 kDa) containing parts of both genes.

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