Merck ANG-2 human

ANG-2 human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)

ANGPT-2

생물학적 소스

human

재조합

expressed in CHO cells

assay

≥95% (SDS-PAGE)

form

lyophilized powder

분자량

60-70 kDa

포장

pkg of 10 μg
pkg of 50 μg

UniProt 수납 번호

O15123

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... ANGPT2(285)

ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as a n agonist or antagonist of Tie2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an α helix rich “coiled coil” N-terminal domain and fibrinogen like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0– 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein.