Merck QCM 3 µm Endothelial Cell Migration Assay Fibronectin, Colorimetric

QCM 3 µm Endothelial Cell Migration Assay Fibronectin, Colorimetric

This QCM 3 μm Endothelial Cell Migration Assay – Fibronectin, Colorimetric is ideal for the study of endothelial cell migration in response to an angiogenic stimulus.

Quality Level

100

manufacturer/tradename

Chemicon®
QCM

technique(s)

cell based assay: suitable

detection method

colorimetric
fluorometric

배송 상태

wet ice

Also available: Cell Comb Scratch Assay! Get biochemical data from a scratch assay!Click Here

Introduction
Angiogenesis is a fundamental process involving the growth of new blood vessels from pre-existing vessels. It is important in development and wound healing, as well as pathologic diseases such as diabetic retinopathy and cancer. During angiogenesis, endothelial cells need to move out of existing vessels, migrate into new areas, proliferate and assemble into new capillaries. The migration of endothelial cells is regulated by many angiogenic factors and anti-angiogenic factors. It is critical for researchers to understand the mechanisms of endothelial cell migration.

Millipore′s 3 μm QCM Endothelial Cell Migration Assay – Fibronectin, Colorimetric provides a quick and efficient system to study the ability of compounds to induce or inhibit endothelial cell migration. This assay also allows screening of pharmacological agents, evaluation of integrins or other adhesion receptors responsible for endothelial cell migration, analysis of gene function in transfected cells, and determination of ECM protein involvement in cell movement.

This versatile assay permits counting of individual migratory cells, and, more importantly, allows quantitative analysis by optical density (OD) using a standard microplate reader. This convenient assay allows large scale screening and quantitative comparison of multiple samples and includes individual migration controls for each sample.