Thermo Fisher Scientific Active/Pro-Caspase 3 Recombinant Rabbit Monoclonal Antibody (ARC0133)
Active/Pro-Caspase 3 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 높은 특이성과 재현성을 제공합니다. 액상 형태로 -20°C에서 보관하며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Active/Pro-Caspase 3 Recombinant Rabbit Monoclonal Antibody (ARC0133)
Applications and Tested Dilution
- Western Blot (WB): 1:1,000–1:2,000
- ELISA: 1 µg/mL
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Algae |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0133 |
| Immunogen | Recombinant fusion protein containing amino acids 29–175 of human Caspase-3 (P42574) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.05 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2849235 |
Product Specific Information
Immunogen sequence:
SGISLDNSYK MDYPEMGLCI IINNKNFHKS TGMTSRSGTD VDAANLRETF RNLKYEVRNK NDLTREEIVE LMRDVSKEDH SKRSSFVCVL LSHGEEGIIF GTNGPVDLKK ITNFFRGDRC RSLTGKPKLF IIQACRGTEL DCGIETD
Target Information
This gene encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing to produce large and small subunits, which dimerize to form the active enzyme.
Caspase-3 cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10. It is the predominant caspase involved in cleavage of amyloid-beta 4A precursor protein, associated with neuronal death in Alzheimer’s disease. Alternative splicing results in two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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