Thermo Fisher Scientific Active/Pro-Caspase 3 Recombinant Rabbit Monoclonal Antibody (ARC0133)

Thermo Fisher Scientific Active/Pro-Caspase 3 Recombinant Rabbit Monoclonal Antibody (ARC0133)

Applications and Tested Dilution

• Western Blot (WB): 1:1,000–1:2,000
• ELISA: 1 µg/mL

Publications

• View 1 publication

Product Specifications

Product Specific Information

Immunogen sequence:
SGISLDNSYK MDYPEMGLCI IINNKNFHKS TGMTSRSGTD VDAANLRETF RNLKYEVRNK NDLTREEIVE LMRDVSKEDH SKRSSFVCVL LSHGEEGIIF GTNGPVDLKK ITNFFRGDRC RSLTGKPKLF IIQACRGTEL DCGIETD

Target Information

This gene encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing to produce large and small subunits, which dimerize to form the active enzyme.
Caspase-3 cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10. It is the predominant caspase involved in cleavage of amyloid-beta 4A precursor protein, associated with neuronal death in Alzheimer’s disease. Alternative splicing results in two transcript variants encoding the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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