Thermo Fisher Scientific ATG12 Monoclonal Antibody (GT948)
ATG12 단백질을 인식하는 mouse monoclonal antibody로, Western blot 및 Immunocytochemistry에 적합합니다. Human과 Mouse에 반응하며, Protein G로 정제된 1 mg/mL 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT948 |
| Immunogen | Recombinant protein corresponding to human ATG12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787125 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Pig (81%), Chimpanzee (96%)
- Positive Control: 293T, A431, HeLa, HepG2, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ATG12 is a member of the autophagy protein family and forms a conjugate with ATG5, exhibiting ubiquitin-protein ligase (E3)-like activity for protein lipidation during autophagy. This conjugate interacts with innate immune response proteins such as RIG-I and VISA (IPS-1), inhibiting type I interferon production and enabling viral replication. ATG12 also interacts with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known. Autophagy, a process of bulk degradation of cellular proteins via the autophagosomic-lysosomal pathway, is crucial for normal growth control and may be defective in tumor cells. It supports nutrient preservation under starvation and normal cytosolic turnover. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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