Thermo Fisher Scientific TET2 Monoclonal Antibody (GT442)
TET2 단백질을 인식하는 Mouse monoclonal antibody (Clone GT442). Western blot 및 Immunoprecipitation에 적합. Human 시료 반응성. Protein G 정제, 1 mg/mL 농도, PBS buffer. 연구용으로 DNA 탈메틸화 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT442 |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human TET2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787127 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: DDDDK-human TET2-transfected 293T.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), playing a key role in active DNA demethylation.
TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs and mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC).
This process constitutes the initial step in cytosine demethylation.
Additionally, TET2 recruits O-GlcNAc transferase (OGT) to CpG-rich transcription start sites of active genes, promoting histone H2B GlcNAcylation.
Mutations in TET2 are associated with Polycythemia vera and Myelodysplastic syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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