Thermo Fisher Scientific Phospho-STAT6 (Thr645) Polyclonal Antibody
STAT6 Thr645 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP에 사용 가능. 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관.
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Thermo Fisher Scientific Phospho-STAT6 (Thr645) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunoprecipitation (IP) | 2–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide surrounding the epitope with phosphorylation sites at Thr645 of STAT6 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: HepG2
- Cellular location: Nuclear
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL-13. STAT6 knockout models (Stat6-/-) show deficiency in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4-mediated proliferation.
STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
STAT6 is critically involved in Th2 immune response and is crucial for IL-4-mediated biological responses. It naturally occurs in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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