Thermo Fisher Scientific STAT4 Polyclonal Antibody
STAT4 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, IP에 적합. 인간 및 마우스 시료 반응성. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. IL-12 관련 STAT4 신호전달 연구에 활용 가능.
- 카탈로그번호
- 500-12194
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific STAT4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunoprecipitation (IP) | 2–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the C-terminus of STAT4 protein from human |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Mouse kidney
- Cellular location: Nuclear
Target Information
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 is similar to other STAT family members in that it can be tyrosine phosphorylated by Jak1 or Jak2. STAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis.
STAT4 is activated by the cytokine interleukin 12 (IL-12), which is required for the T-cell independent induction of IFN-gamma, a key step in suppressing bacterial and parasitic infections. IL-12 is also essential for Th1 response development, crucial for host defense against intracellular pathogens. STAT4-deficient mice show impaired IL-12-mediated Th1 development and enhanced Th2 differentiation. In response to viral infection, IFN-α/β activation of STAT4 is required for IFN-γ production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.