Thermo Fisher Scientific Bcl-X (Apoptosis Marker) Monoclonal Antibody (rBCL2L1/4508)
Bcl-X 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에서 아폽토시스 마커 분석에 적합. IHC(PFA 고정)에서 1–2 µg/mL로 사용 가능. 단클론 Mouse IgG2a 항체이며, 4°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (PFA fixed)
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rBCL2L1/4508 |
| Immunogen | Recombinant fragment (around aa1–100) of human BCL2L1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the BCL-X gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
These proteins are located at the outer mitochondrial membrane and regulate the opening of the mitochondrial membrane channel (VDAC).
VDAC controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release—key inducers of apoptosis.
Alternative splicing results in multiple transcript variants encoding two isoforms:
- Longer isoform: acts as an apoptotic inhibitor
- Shorter isoform: acts as an apoptotic activator
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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