Thermo Fisher Scientific Torc1 Monoclonal Antibody (4G9)
Torc1 단백질을 인식하는 4G9 클론의 마우스 모노클로날 항체로, Western blot, ICC/IF, Flow cytometry, IP에 적합합니다. Human 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Torc1 Monoclonal Antibody (4G9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G9 |
| Immunogen | Synthetic peptide corresponding to the N-terminus of Human TORC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2717306 |
Product Specific Information
The antibody was affinity-purified from mouse ascites by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Torc1 acts as a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It functions in the SIK/TORC signaling pathway, active when dephosphorylated, and independent of CREB1 Ser-133 phosphorylation. Enhances CREB1 interaction with TAF4 and regulates CREB-activated genes such as StAR. It is a potent coactivator of PGC1α and promotes mitochondrial biogenesis in muscle cells. In the hippocampus, Torc1 contributes to late-phase long-term potentiation (L-LTP) maintenance and may be required for dendritic growth of developing cortical neurons. Together with SIK1, it regulates light-induced entrainment of the circadian clock by coactivating CREB-mediated transcription of PER1.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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