Thermo Fisher Scientific Bcl-2 (Apoptosis and Follicular Lymphoma Marker) Monoclonal Antibody (SPM117)
인간 Bcl-2 단백질을 인식하는 단클론 항체로, 세포자멸사 및 여포성 림프종 연구에 적합. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. Mouse 및 Rat과 반응하지 않으며, 단백질 A/G로 정제된 액상 형태.
- 카탈로그번호
- 596-MSM1X-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Bcl-2 (Apoptosis and Follicular Lymphoma Marker) Monoclonal Antibody (SPM117)
Thermo Fisher Scientific Bcl-2 (Apoptosis and Follicular Lymphoma Marker) Monoclonal Antibody (SPM117)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM117 |
| Immunogen | Synthetic peptide aa41–54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse or Rat.
Target Information
BCL-2 is a key regulator of apoptosis that can inhibit or promote cell death. Members of the BCL-2 family form dimers to modulate apoptosis. Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak are involved in cytochrome c release from mitochondria, initiating apoptosis. Constitutive expression of BCL-2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, while normal germinal centers are negative. Two transcript variants produced by alternate splicing differ at their C-terminal ends. Overexpression of BCL-2 is linked to cancers such as B-cell lymphoma and prostate cancer.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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