Thermo Fisher Scientific Bcl-2 (Apoptosis and Follicular Lymphoma Marker) Monoclonal Antibody (8C8)
Bcl-2 단백질을 표적하는 Thermo Fisher의 8C8 단클론 항체로, apoptosis 및 follicular lymphoma 연구에 적합. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. Human, primate, pig 반응성. Protein A/G 정제, PBS 용액 형태로 제공.
- 카탈로그번호
- 596-MSM2-P1ABX
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Pig |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8C8 |
| Immunogen | Synthetic peptide, aa41–54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse or Rat
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. Members of the BCL-2 family dimerize to modulate apoptosis. Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak are involved in cytochrome c release from mitochondria, initiating apoptosis. Constitutive expression of BCL-2, often due to translocation to the Ig heavy chain locus, is associated with follicular lymphoma. Neoplastic germinal centers in follicular lymphoma express high levels of BCL-2 alpha protein, whereas normal centers are negative. Overexpression of BCL-2 has been linked to cancers such as B-cell lymphoma and prostate cancer. Two transcript variants of BCL-2 differ in their C-terminal ends.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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