Thermo Fisher Scientific Phospho-NPM1 (Ser4) Polyclonal Antibody
인산화된 Ser4 위치의 NPM1 단백질을 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 사람, 생쥐, 랫트 시료에 반응합니다. PBS 버퍼(50% glycerol) 보존, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NPM1 (Accession P06748), corresponding to amino acid residues around phosphorylated Ser4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817592 |
Product Specific Information
This antibody detects endogenous levels of Nucleophosmin only when phosphorylated at Ser4.
Target Information
NPM1 (Nucleophosmin 1, also known as B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in multiple cellular processes, including:
- Ribosome assembly and transport
- Cytoplasmic/nuclear trafficking
- Regulation of DNA polymerase alpha activity
- Centrosome duplication
- p53 regulation
NPM1 continuously shuttles between the nucleus, cytoplasm, and nucleolus, acting as a chaperone for core histones. It binds nucleic acids, prevents protein aggregation, and facilitates protein renaturation after denaturation. NPM1 is associated with centrosome duplication and is a substrate of CDK2/cyclin E.
Mutations or dysfunction in NPM1 are linked to diseases such as acute myeloid leukemia and lymphomatoid papulosis. It also participates in fusion proteins (e.g., NPM-ALK, NPM-RAR, NPM-MLF1) associated with tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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