Thermo Fisher Scientific Phospho-PDE3A (Ser312) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PDE3A(Accession Q14432), corresponding to amino acid residues around phosphorylated Ser312. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PDE3A,uniProtId:Q14432-1,ncbiNodeId:9606,antigenRange:312,antigenLength:1141,antigenImageFileName:PA5-106199_PDE3A_Q14432-1_Rabbit.svg,antigenImageFileNamePDP:PA5-106199_PDE3A_Q14432-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817597

Product Specific Information

Antibody detects endogenous levels of PDE3A only when phosphorylated at Ser312.

Target Information

Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents (Meacci et al., 1992 [PubMed 1315035]).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.