Thermo Fisher Scientific Phospho-NPM1 (Thr237) Polyclonal Antibody
인산화된 Thr237 부위의 NPM1 단백질을 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF에 적합하며 사람, 생쥐, 랫트 시료에 반응합니다. 고순도 정제 및 안정적 PBS/glycerol buffer 보존으로 높은 재현성과 신뢰성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 – 1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 – 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 – 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NPM1 (Accession P06748), corresponding to amino acid residues around phosphorylated Thr237. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817594 |
Product Specific Information
This antibody detects endogenous levels of Nucleophosmin only when phosphorylated at Thr237.
Target Information
NPM1 (Nucleophosmin 1, also known as B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in:
- Ribosome assembly and transport
- Cytoplasmic/nuclear trafficking
- Regulation of DNA polymerase alpha activity
- Centrosome duplication
- p53 regulation
NPM1 shuttles between the nucleus, cytoplasm, and nucleolus, acting as a chaperone for core histones. It binds nucleic acids, prevents protein aggregation, and facilitates refolding of denatured proteins. NPM1 is also associated with centrosome duplication and serves as a substrate of CDK2/cyclin E. Abnormal NPM1 function is implicated in diseases such as acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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